(19)

(11)

EP 4 280 932 A1

(12)

(43) Date of publication: 29.11.2023 Bulletin 2023/48 (21) Application number: 22743016.2 (22) Date of filing: 17.01.2022

(51) International Patent Classification (IPC):  A61B 1/06(2006.01) A61B 1/015(2006.01) A61B 1/00(2006.01) (52) Cooperative Patent Classification (CPC): A61B 1/00087; A61B 1/00135; A61B 1/0684; A61B 1/0669; A61B 1/3132; A61B 90/30; A61B 17/3474; A61B 2017/00057; A61B 2017/3454; A61B 17/3417; A61B 2090/306; A61B 2090/309; A61B 2090/3612 (86) International application number: PCT/US2022/012652 (87) International publication number: WO 2022/159351 (28.07.2022 Gazette 2022/30)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.01.2021 US 202163139298 P 06.07.2021 US 202117368296 14.10.2021 US 202117501232 (71) Applicant: The Brigham and Women's Hospital Boston, MA 02115 (US)	(72) Inventor: EINARSSON, Jon, I. Boston, MA 02215 (US) (74) Representative: Guardian IP Consulting I/S  Diplomvej, Building 381 2800 Kgs. Lyngby 2800 Kgs. Lyngby (DK)