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EP 4 284 798 A1

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(43) Date of publication: 06.12.2023 Bulletin 2023/49 (21) Application number: 22705222.2 (22) Date of filing: 26.01.2022

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61P 35/00(2006.01) A61K 31/4985(2006.01) C07D 487/04(2006.01) A61K 31/437(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; C07D 487/04; A61P 35/00 (86) International application number: PCT/US2022/013946 (87) International publication number: WO 2022/164934 (04.08.2022 Gazette 2022/31)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.01.2021 US 202163141634 P (71) Applicant: The USA, as represented by The Secretary, Department of Health and Human Services Bethesda, MD 20892-7660 (US)

(72) Inventors: ZHAO, Xuezhi Bethesda, MD 20892-7660 (US) WANG, Wenjie Bethesda, MD 20892-7660 (US) LOUNTOS, George, Themistoclis Frederick, MD 21702-1201 (US) KISELEV, Evgeny, Anatolyevich Bethesda, MD 20892-7660 (US) WAUGH, David, Spencer Bethesda, MD 20892-7660 (US) POMMIER, Yves, Georges Bethesda, MD 20892-7660 (US) BURKE, Terrence, Richard, Jr. Bethesda, MD 20892-7660 (US) (74) Representative: Harris, Oliver John Richard  Novagraaf UK Centrum Norwich Research Park Colney Lane Norwich NR4 7UG Norwich NR4 7UG (GB)