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(11)

EP 4 288 555 A1

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(43) Date of publication: 13.12.2023 Bulletin 2023/50 (21) Application number: 22705501.9 (22) Date of filing: 04.02.2022

(51) International Patent Classification (IPC):  C12N 15/864(2006.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): C12N 2750/14143; C12N 15/113; C12N 2320/32; C12N 2310/141; C12N 2330/51; C12N 15/86; C12N 2830/38; C12N 2830/50 (86) International application number: PCT/US2022/015380 (87) International publication number: WO 2022/170146 (11.08.2022 Gazette 2022/32)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.02.2021 US 202163146522 P 05.02.2021 WO PCT/US2021/016939 (71) Applicant: Maze Therapeutics, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: GOOLD, Carleton Proctor South San Francisco, California 94080 (US) GRAHAM, Robert R. South San Francisco, California 94080 (US) JANKI, Peter South San Francisco, California 94080 (US) CHEN, Ronald South San Francisco, California 94080 (US) GREEN, Eric South San Francisco, California 94080 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)