(19)

(11)

EP 4 291 028 A1

(12)

(43) Date of publication: 20.12.2023 Bulletin 2023/51 (21) Application number: 22711117.6 (22) Date of filing: 09.02.2022

(51) International Patent Classification (IPC):  A01N 1/02(2006.01) (52) Cooperative Patent Classification (CPC): A01N 1/0284; A01N 1/0221; A01N 1/0242 (86) International application number: PCT/US2022/015870 (87) International publication number: WO 2022/173867 (18.08.2022 Gazette 2022/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.02.2021 US 202163147737 P 08.02.2022 WO PCT/US2022/015627 (71) Applicant: Takeda Pharmaceutical Company Limited Osaka 540-8645 (JP)	(72) Inventors: ZHOU, Shuxia Cambridge, MA 02139 (US) CAO, Lan Cambridge, MA 02139 (US) GAO, Dayong Cambridge, MA 02139 (US) XUE, Qiong Cambridge, MA 02139 (US) SUN, Jiusong Cambridge, MA 02139 (US) ZHU, Huang Cambridge, MA 02139 (US) (74) Representative: Jones, Nicholas Andrew  Withers & Rogers LLP 2 London Bridge London SE1 9RA London SE1 9RA (GB)