(19)

(11)

EP 4 291 238 A1

(12)

(43) Date of publication: 20.12.2023 Bulletin 2023/51 (21) Application number: 21925220.2 (22) Date of filing: 10.02.2021

(51) International Patent Classification (IPC):  A61K 45/00(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 31/47; A61K 31/519; A61K 31/4439; A61K 31/502; A61K 31/4406; A61K 31/167   C-Sets: A61K 31/4406, A61K 2300/00; A61K 31/167, A61K 2300/00; A61K 31/47, A61K 2300/00; A61K 31/519, A61K 2300/00; A61K 31/4439, A61K 2300/00; A61K 31/502, A61K 2300/00; (86) International application number: PCT/CN2021/076503 (87) International publication number: WO 2022/170557 (18.08.2022 Gazette 2022/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: Great Novel Therapeutics Biotech & Medicals Corporation Taipei City 115011, Taiwan (TW)	(72) Inventors: CHOU, Cheng-han Taipei City 115011 (TW) WU, Yi-hong Taipei City 115011 (TW) CHEN, Jia-shiong Taipei City 115011 (TW) CHAO, Ye-su Taipei City 115011 (TW) CHEN, Chia-nan Taipei City 115011 (TW) (74) Representative: Cabinet Becker et Associés  25, rue Louis le Grand 75002 Paris 75002 Paris (FR)