(19)

(11)

EP 4 291 636 A1

(12)

(43) Date of publication: 20.12.2023 Bulletin 2023/51 (21) Application number: 22705172.9 (22) Date of filing: 11.02.2022

(51) International Patent Classification (IPC):  C12N 5/071(2010.01) G01N 33/50(2006.01) C12N 5/095(2010.01) (52) Cooperative Patent Classification (CPC): C12N 5/0631; C12N 5/0695; C12N 2501/115; C12N 2501/415; C12N 2501/11; C12N 2513/00; C12N 2501/195; C12N 2501/999; C12N 2501/15; C12N 2501/155; C12N 2501/119; G01N 33/5082 (86) International application number: PCT/NL2022/050070 (87) International publication number: WO 2022/173300 (18.08.2022 Gazette 2022/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 11.02.2021 NL 2027546 (71) Applicant: Prinses Máxima Centrum voor Kinderoncologie B.V. 3584 CS Utrecht (NL)	(72) Inventors: RIOS, Anne Caroline 3584 CS Utrecht (NL) DEKKERS, Johanna Florentia 3584 CS Utrecht (NL) BUCHHOLZ, Maj-Britt 3584 CS Utrecht (NL) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)