(19)
(11) EP 4 291 677 A2

(12)

(88) Date of publication A3:
06.10.2022

(43) Date of publication:
20.12.2023 Bulletin 2023/51

(21) Application number: 22705528.2

(22) Date of filing: 08.02.2022
(51) International Patent Classification (IPC): 
C12Q 1/6806(2018.01)
(52) Cooperative Patent Classification (CPC):
C12Q 1/6806
 
C-Sets:
C12Q 1/6806, C12Q 2527/125, C12Q 2537/164;
(86) International application number:
PCT/EP2022/052979
(87) International publication number:
WO 2022/171606 (18.08.2022 Gazette 2022/33)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 09.02.2021 US 202163147307 P
16.02.2021 US 202163150019 P
20.05.2021 US 202163191079 P

(71) Applicants:
  • F. Hoffmann-La Roche AG
    4070 Basel (CH)

    AL AT BE BG CH CY CZ DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR 
  • Roche Diagnostics GmbH
    68305 Mannheim (DE)

    DE 
  • Kapa Biosystems, Inc.
    Wilmington, MA 01887 (US)

(72) Inventors:
  • BERGMANN, Frank
    82377 Penzberg (DE)
  • CHANG, Shwu shin
    Pleasanton, 94588 (US)
  • CRISALLI, Peter
    Pleasanton, 94588 (US)
  • DE BEER, Abre
    Wilmington, Massachusetts 01887 (US)
  • HEINDL, Dieter
    82377 Penzberg (DE)
  • KHAKSHOOR, Omid
    Pleasanton, 94588 (US)
  • PENKLER, David L.
    Pleasanton, California 94588 (US)
  • PENKLER, Jo-Anne
    Pleasanton, 94588 (US)
  • RANIK, Martin
    Pleasanton, 94588 (US)
  • TAING, Meng
    Pleasanton, 94588 (US)

(74) Representative: Hildebrandt, Martin K. E. 
Roche Diagnostics GmbH Nonnenwald 2
82377 Penzberg
82377 Penzberg (DE)

   


(54) METHODS FOR BASE-LEVEL DETECTION OF METHYLATION IN NUCLEIC ACIDS