(19)

(11)

EP 4 291 892 A1

(12)

(43) Date of publication: 20.12.2023 Bulletin 2023/51 (21) Application number: 22753354.4 (22) Date of filing: 10.02.2022

(51) International Patent Classification (IPC):  G01N 33/53(2006.01) (52) Cooperative Patent Classification (CPC): G01N 2800/52; C07K 16/18; G01N 33/6896; G01N 2800/28; G01N 33/6848; C07K 2317/34 (86) International application number: PCT/US2022/015998 (87) International publication number: WO 2022/173965 (18.08.2022 Gazette 2022/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 10.02.2021 US 202163147833 P 03.05.2021 US 202163183417 P 07.06.2021 US 202163197826 P (71) Applicant: Washington University St. Louis, Missouri 63130 (US)	(72) Inventors: BATEMAN, Randall St. Louis, Missouri 63130 (US) BUDELIER, Melissa St. Louis, Missouri 63130 (US) HOLTZMAN, David St. Louis, Missouri 63130 (US) JIANG, Hong St. Louis, Missouri 63130 (US) (74) Representative: Greaves Brewster LLP  Copa House Station Road Cheddar, Somerset BS27 3AH Cheddar, Somerset BS27 3AH (GB)