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(11)

EP 4 301 862 A1

(12)

(43) Date of publication: 10.01.2024 Bulletin 2024/02 (21) Application number: 22715804.5 (22) Date of filing: 01.03.2022

(51) International Patent Classification (IPC):  C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2740/16043; A61K 39/0011; C07K 16/2809; C07K 2317/622; C07K 2319/912; C07K 16/2803; C07K 14/7051; C07K 2319/03; A61K 2039/5258; A61K 2039/5156; A61K 48/005; A61K 48/0058 (86) International application number: PCT/US2022/018404 (87) International publication number: WO 2022/187289 (09.09.2022 Gazette 2022/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 01.03.2021 US 202163200329 P 04.03.2021 WO PCT/US2021/020922 04.06.2021 US 202163197315 P 31.08.2021 WO PCT/US2021/048532 10.09.2021 US 202163261099 P (71) Applicant: EXUMA BIOTECH CORP. West Palm Beach, FL 33401 (US)

(72) Inventors: FROST, Gregory Ian West Palm Beach, Florida 33401 (US) VIGANT, Frederic West Palm Beach, Florida 33401 (US) KUNDU, Anirban West Palm Beach, Florida 33401 (US) HENKELMAN, John R., III Wesst Palm Beach, Florida 33401 (US) KERKAR, Sidharth West Palm Beach, Florida 33401 (US) SCHREIBER, Gregory West Palm Beach, Florida 33401 (US) (74) Representative: Turner, Craig Robert  AA Thornton IP LLP 8th Floor, 125 Old Broad Street London EC2N 1AR London EC2N 1AR (GB)