(19)
(11) EP 4 305 168 A1

(12)

(43) Date of publication:
17.01.2024 Bulletin 2024/03

(21) Application number: 22710115.1

(22) Date of filing: 07.03.2022
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/113; C12N 2310/11; C12N 2310/315; C12N 2310/3231; C12N 2310/341; C12N 2310/346; C12N 2320/11; C12N 2320/53
 
C-Sets:
C12N 2310/321, C12N 2310/3525;
(86) International application number:
PCT/EP2022/055770
(87) International publication number:
WO 2022/189363 (15.09.2022 Gazette 2022/37)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 08.03.2021 EP 21315033
17.08.2021 EP 21306123

(71) Applicant: Les Laboratoires Servier
92284 Suresnes Cedex (FR)

(72) Inventors:
  • TRAN, Hélène
    92150 Suresnes (FR)
  • CHANRION, Benjamin
    31170 Tournefeuille (FR)
  • LOTFI, Sofia
    91210 Draveil (FR)
  • DAS DORES, Guillaume
    78300 Poissy (FR)
  • DORVAL, Thierry
    75014 Paris (FR)
  • GUIGNARD, Raphaël
    91400 Orsay (FR)

   


(54) ANTISENSE OLIGONUCLEOTIDES FOR INHIBITING ALPHA-SYNUCLEIN EXPRESSION