(19)

(11)

EP 4 313 101 A1

(12)

(43) Date of publication: 07.02.2024 Bulletin 2024/06 (21) Application number: 22782030.5 (22) Date of filing: 29.03.2022

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) A61K 38/08(2019.01) A61K 38/10(2006.01) A61K 38/04(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/00; C07K 14/4736; A61P 35/00; A61K 45/06 (86) International application number: PCT/US2022/022363 (87) International publication number: WO 2022/212389 (06.10.2022 Gazette 2022/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.03.2021 US 202117215845 (71) Applicant: Saint Leo University Saint Leo FL 33574-6665 (US)	(72) Inventor: BORYSOV, Sergiy Tampa, FL 33618 (US) (74) Representative: Botti & Ferrari S.p.A.  Via Cappellini, 11 20124 Milano 20124 Milano (IT)