(19)
(11) EP 4 314 041 A1

(12)

(43) Date of publication:
07.02.2024 Bulletin 2024/06

(21) Application number: 21720353.8

(22) Date of filing: 30.03.2021
(51) International Patent Classification (IPC): 
C07K 14/755(2006.01)
A61K 38/00(2006.01)
 A61P 7/04(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 14/755; A61K 38/00; A61P 7/04
(86) International application number:
PCT/US2021/024916
(87) International publication number:
WO 2022/211791 (06.10.2022 Gazette 2022/40)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(71) Applicant: AAVNERGENE INC.
North Bethesda, MD 20852 (US)

(72) Inventors:
  • WANG, Qizhao
    Rockville, MD 20850 (US)
  • YU, Daozhan
    Ellicott City, MD 21042 (US)

(74) Representative: Brand Murray Fuller LLP 
50 Eastcastle Street
London W1W 8EA
London W1W 8EA (GB)

   


(54) MODIFIED PLASMA CLOTTING FACTOR VIII AND METHOD OF USE THEREOF