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(11)

EP 4 314 820 A1

(12)

(43) Date of publication: 07.02.2024 Bulletin 2024/06 (21) Application number: 22712620.8 (22) Date of filing: 24.03.2022

(51) International Patent Classification (IPC):  G01N 33/543(2006.01) G01N 33/544(2006.01) A61K 49/00(2006.01) C12Q 1/6876(2018.01) G01N 33/531(2006.01) A61K 48/00(2006.01) C12Q 1/6844(2018.01) (52) Cooperative Patent Classification (CPC): G01N 33/531; G01N 33/5438; G01N 33/544; C12Q 1/6876; C12Q 1/6806   C-Sets: C12Q 1/6806, C12Q 2521/101, C12Q 2521/125, C12Q 2521/319, C12Q 2521/501; (86) International application number: PCT/GB2022/050735 (87) International publication number: WO 2022/200793 (29.09.2022 Gazette 2022/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 25.03.2021 GB 202104219 04.11.2021 WO PCT/GB2021/052870 (71) Applicant: The University of Birmingham Birmingham, West Midlands B15 2TT (GB)	(72) Inventors: ALBRECHT, Tim Birmingham, West Midlands B15 2TT (GB) IRVING, Oliver Birmingham, West Midlands B15 2TT (GB) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)