(19)

(11)

EP 4 314 831 A2

(12)

(88) Date of publication A3: 01.12.2022 (43) Date of publication: 07.02.2024 Bulletin 2024/06 (21) Application number: 22723227.9 (22) Date of filing: 25.03.2022

(51) International Patent Classification (IPC):  G01N 33/574(2006.01) A61K 39/395(2006.01) A61K 39/39(2006.01) G01N 33/569(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/574; A61K 39/001134; A61K 2039/505; G01N 2333/495; G01N 2800/52; G01N 33/56972; G01N 33/74; G01N 33/5011; A61K 2039/507; C07K 16/22; C07K 16/2818; C07K 2317/76; C07K 16/2827 (86) International application number: PCT/US2022/022063 (87) International publication number: WO 2022/204581 (29.09.2022 Gazette 2022/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.03.2021 US 202163166824 P 03.06.2021 US 202163202260 P 25.01.2022 US 202263302999 P 24.02.2022 US 202263313386 P (71) Applicant: Scholar Rock, Inc. Cambridge, MA 02142 (US)

(72) Inventors: LEE-HOEFLICH, Si Tuen Cambridge, Massachusetts 02142 (US) BRUECKNER, Christopher Cambridge, Massachusetts 02142 (US) MARTIN, Constance Cambridge, Massachusetts 02142 (US) FAUCETTE, Ryan Cambridge, Massachusetts 02142 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)