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EP 4 320 272 A1

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(43) Date of publication: 14.02.2024 Bulletin 2024/07 (21) Application number: 22779318.9 (22) Date of filing: 22.03.2022

(51) International Patent Classification (IPC):  C12Q 1/6844(2018.01) C12R 1/16(2006.01) C12Q 1/6876(2018.01) (52) Cooperative Patent Classification (CPC): C12R 2001/16; C12Q 1/6844; C12Q 1/689   C-Sets: C12Q 1/6844, C12Q 2527/101; (86) International application number: PCT/IN2022/050276 (87) International publication number: WO 2022/208531 (06.10.2022 Gazette 2022/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 31.03.2021 IN 202111015391 (71) Applicant: Indian Council of Medical Research New Delhi 110029 (IN)

(72) Inventors: NANDI, Shyam Sundar Mumbai 400012 (IN) ROY, Subarna Chennai 600077 (IN) LAMBE, Upendra Mumbai 400012 (IN) SAWANT, Sonali Ankush Mumbai 400012 (IN) GOHIL, Trupti Mumbai 400012 (IN) MURHEKAR, Manoj Chennai 600077 (IN) DESHPANDE, Jagadish Mumbai 400012 (IN) (74) Representative: Mummery, Thomas Zack  Reddie & Grose LLP The White Chapel Building 10 Whitechapel High Street London E1 8QS London E1 8QS (GB)