(19)

(11)

EP 4 320 618 A2

(12)

(88) Date of publication A3: 29.12.2022 (43) Date of publication: 14.02.2024 Bulletin 2024/07 (21) Application number: 22785557.4 (22) Date of filing: 08.04.2022

(51) International Patent Classification (IPC):  G16B 30/20(2019.01) C12Q 1/6886(2018.01) C12Q 1/6869(2018.01) (52) Cooperative Patent Classification (CPC): G16B 20/20; G16B 25/10; G16B 30/10; G16B 40/20; G16H 20/10; G16H 50/20 (86) International application number: PCT/US2022/024082 (87) International publication number: WO 2022/217096 (13.10.2022 Gazette 2022/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.04.2021 US 202163172590 P 05.11.2021 US 202163276378 P (71) Applicant: Fred Hutchinson Cancer Center Seattle, WA 98109 (US)

(72) Inventors: HA, Gavin Seattle, Washington 98109 (US) MACPHERSON, David Seattle, Washington 98109 (US) NELSON, Peter S. Seattle, Washington 98109 (US) DOEBLEY, Anna-Lisa Seattle, Washington 98109 (US) HIATT, Joseph B. Seattle, Washington 98109 (US) DE SARKAR, Navonil Seattle, Washington 98109 (US) PATTON, Robert Seattle, Washington 98109 (US) (74) Representative: MacLean, Martin Robert et al Mathys & Squire The Shard32 London Bridge StreetLondon SE1 9SG The Shard32 London Bridge StreetLondon SE1 9SG (GB)