(19)

(11)

EP 4 323 012 A1

(12)

(43) Date of publication: 21.02.2024 Bulletin 2024/08 (21) Application number: 22788858.3 (22) Date of filing: 13.04.2022

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 15/87(2006.01) C07H 21/04(2006.01) A61K 38/46(2006.01) C12N 15/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 48/005; C12N 9/22; C12N 5/0621; C12N 2510/00; C12N 2506/02; C12N 2710/14043; C12N 15/1138; C12N 2310/20; C12N 15/86; A61P 27/02; A61K 38/00; C07K 14/705 (86) International application number: PCT/US2022/024622 (87) International publication number: WO 2022/221411 (20.10.2022 Gazette 2022/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.04.2021 US 202163174090 P (71) Applicants: The Trustees of Columbia University in the City of New York New York, NY 10027 (US) University of Rochester Rochester, NY 14642 (US)

(72) Inventors: YANG, Tingting New York, New York 10027 (US) TSANG, Stephen, H. New York, New York 10027 (US) ZHANG, Yu New York, New York 10027 (US) (74) Representative: CH Kilger Anwaltspartnerschaft mbB  Fasanenstraße 29 10719 Berlin 10719 Berlin (DE)