(19)

(11)

EP 4 323 505 A1

(12)

(43) Date of publication: 21.02.2024 Bulletin 2024/08 (21) Application number: 22721981.3 (22) Date of filing: 18.04.2022

(51) International Patent Classification (IPC):  C12N 5/0793(2010.01) (52) Cooperative Patent Classification (CPC): C12N 5/0619; C12N 2506/02; C12N 2506/08; C12N 2506/45; C12N 2501/72; C12N 2501/155; C12N 2501/16; C12N 2501/415; C12N 2501/119; C12N 2501/599; C12N 2501/41; C12N 2533/52 (86) International application number: PCT/US2022/025224 (87) International publication number: WO 2022/221765 (20.10.2022 Gazette 2022/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.04.2021 US 202163176006 P (71) Applicant: Brainxell, Inc. Madison, WI 53711-1067 (US)	(72) Inventor: DU, Zhong-Wei Madison, Wisconsin 53711 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)