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EP 4 326 708 A1

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(43) Date of publication: 28.02.2024 Bulletin 2024/09 (21) Application number: 22721132.3 (22) Date of filing: 22.04.2022

(51) International Patent Classification (IPC):  C07D 257/04(2006.01) A61P 9/00(2006.01) A61P 29/00(2006.01) A61P 37/08(2006.01) A61K 31/4439(2006.01) A61P 1/00(2006.01) A61P 9/12(2006.01) A61P 35/00(2006.01) A61K 31/50(2006.01) A61K 31/41(2006.01) (52) Cooperative Patent Classification (CPC): C07D 257/04; A61P 1/00; A61P 29/00; A61P 35/00; A61P 37/08; A61P 9/00; A61P 9/12 (86) International application number: PCT/IB2022/053772 (87) International publication number: WO 2022/224212 (27.10.2022 Gazette 2022/43)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.04.2021 GB 202105846 (71) Applicant: Heptares Therapeutics Limited Cambridge, Cambridgeshire CB21 6DG (GB)

(72) Inventors: CONGREVE, Miles Stuart Cambridge Cambridgeshire CB21 6DG (GB) SWAIN, Nigel Alan Cambridge Cambridgeshire CB21 6DG (GB) BROWN, Giles Albert Cambridge Cambridgeshire CB21 6DG (GB) WHITEHURST, Benjamin Cambridge Cambridgeshire CB21 6DG (GB) FLANAGAN, Neil John Cambridge Cambridgeshire CB21 6DG (GB) (74) Representative: Sardharwala, Fatema Elyasali  GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)