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EP 4 330 250 A1

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(43) Date of publication: 06.03.2024 Bulletin 2024/10 (21) Application number: 22727008.9 (22) Date of filing: 28.04.2022

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) C07D 491/10(2006.01) A61K 31/416(2006.01) C07D 405/14(2006.01) C07D 495/10(2006.01) A61P 31/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/14; C07D 405/14; C07D 491/10; C07D 495/10; A61P 31/00 (86) International application number: PCT/EP2022/061379 (87) International publication number: WO 2022/229341 (03.11.2022 Gazette 2022/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.04.2021 EP 21171155 (71) Applicant: Boehringer Ingelheim International GmbH 55216 Ingelheim am Rhein (DE)

(72) Inventors: CAROTTA, Sebastian 55216 Ingelheim am Rhein (DE) DAHMANN, Georg 55216 Ingelheim am Rhein (DE) GODBOUT, Cédrickx 55216 Ingelheim am Rhein (DE) HANDSCHUH, Sandra Ruth 55216 Ingelheim am Rhein (DE) NAR, Herbert 55216 Ingelheim am Rhein (DE) OOST, Thorsten 55216 Ingelheim am Rhein (DE) REISER, Ulrich 55216 Ingelheim am Rhein (DE) TREU, Matthias 55216 Ingelheim am Rhein (DE) (74) Representative: Lutze, Oliver et al Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)