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EP 4 330 254 A1

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(43) Date of publication: 06.03.2024 Bulletin 2024/10 (21) Application number: 22722649.5 (22) Date of filing: 25.04.2022

(51) International Patent Classification (IPC):  C07D 413/14(2006.01) A61K 31/513(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 413/14; A61P 35/00 (86) International application number: PCT/US2022/026103 (87) International publication number: WO 2022/232004 (03.11.2022 Gazette 2022/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.04.2021 US 202163179723 P (71) Applicant: Constellation Pharmaceuticals, Inc. Boston, MA 02210 (US)

(72) Inventors: LEVELL, Julian, R. Arlington, MA 02474 (US) COFFIN, Aaron Everett, MA 02149 (US) ZABLOCKI, Mary-Margaret Revere, MA 02151 (US) WILSON, Jonathan, E. Arlington, MA 02474 (US) KHANNA, Avinash Cambridge, MA 02141 (US) GUERIN, David, J. Cambridge, MA 02142 (US) MCELROY, William, T. Framingham, MA 01701 (US) ROCNIK, Jennifer, L. Cambridge, MA 02142 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)