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EP 4 333 843 A1

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(43) Date of publication: 13.03.2024 Bulletin 2024/11 (21) Application number: 22718348.0 (22) Date of filing: 13.03.2022

(51) International Patent Classification (IPC):  A61K 31/427(2006.01) A61P 5/00(2006.01) A61P 25/00(2006.01) C07D 417/04(2006.01) A61K 45/06(2006.01) A61P 17/02(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/427; A61K 45/06; A61P 35/00; A61P 25/00; A61P 5/00; A61P 17/02; C07D 277/42   C-Sets: A61K 31/427, A61K 2300/00; (86) International application number: PCT/US2022/020086 (87) International publication number: WO 2022/240476 (17.11.2022 Gazette 2022/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.05.2021 US 202163187979 P (71) Applicant: University of South Carolina Columbia, SC 29208 (US)	(72) Inventors: SAHIN, Ozgur Columbia, SC 29208 (US) MCINNES, Campbell Columbia, SC 29208 (US) SAATCI, Ozge Columbia, SC 29208 (US) BENEKER, Chad Columbia, SC 29208 (US) REZAEIAN, Abdol-Hossein Columbia, SC 29208 (US) CETIN, Metin Columbia, SC 29208 (US) (74) Representative: Canzler & Bergmeier Patentanwälte Partnerschaft mbB  Despag-Straße 6 85055 Ingolstadt 85055 Ingolstadt (DE)