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(11)

EP 4 340 885 A1

(12)

(43) Date of publication: 27.03.2024 Bulletin 2024/13 (21) Application number: 22805638.8 (22) Date of filing: 20.05.2022

(51) International Patent Classification (IPC):  A61K 47/50(2017.01) C01G 23/047(2006.01) C07D 307/91(2006.01) A61K 47/02(2006.01) C01G 45/02(2006.01) A61P 25/24(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/24; C01G 45/02; C01G 9/02; C01P 2004/45; C01P 2004/03; C01P 2004/04; C01P 2006/40; C01P 2004/62; C01P 2004/61; A61K 9/5115; A61K 9/5146 (86) International application number: PCT/US2022/030383 (87) International publication number: WO 2022/246285 (24.11.2022 Gazette 2022/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.05.2021 US 202163191586 P 21.05.2021 US 202163191759 P (71) Applicant: The Trustees Of Columbia University In The City Of New York New York, NY 10027 (US)	(72) Inventors: LEONG, Kam W. New York, New York 10032 (US) YANG, Letao New York, New York 10032 (US) ZHU, Yuefei New York, New York 10032 (US) (74) Representative: CH Kilger Anwaltspartnerschaft mbB  Fasanenstraße 29 10719 Berlin 10719 Berlin (DE)