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EP 4 346 849 A2

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(88) Date of publication A3: 09.02.2023 (43) Date of publication: 10.04.2024 Bulletin 2024/15 (21) Application number: 22811757.8 (22) Date of filing: 18.05.2022

(51) International Patent Classification (IPC):  A61K 35/12(2015.01) A61K 35/39(2015.01) A61K 35/14(2015.01) A61K 35/545(2015.01) (52) Cooperative Patent Classification (CPC): G16H 50/20; G16H 70/40; G16B 25/10; G01N 33/5073; C12N 2506/45; C12N 5/0676; C12N 5/0696; C12N 2510/00; A61K 35/39; A61P 3/10 (86) International application number: PCT/TR2022/050442 (87) International publication number: WO 2022/250631 (01.12.2022 Gazette 2022/48)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 25.05.2021 TR 202108597 (71) Applicant: T.C. Ankara Universitesi Rektorlugu Ankara (TR)	(72) Inventors: KILIC, Pelin Cevizlidere Ankara (TR) TUNCER, Gizem Cevizlidere Ankara (TR) KILINC, Bugrahan Regaip Cevizlidere Ankara (TR) ALTIOK, Doruk Cevizlidere Ankara (TR) COSAR, Begum Cevizlidere Ankara (TR) (74) Representative: Kaya, Erdem  Erdem Kaya Patent Inc. Konak Mahallesi Kudret Sk. Elitpark Park Sit. Ofisler Apt. No: 12/27 16110 Nilüfer/Bursa 16110 Nilüfer/Bursa (TR)