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EP 4 347 655 A1

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(43) Date of publication: 10.04.2024 Bulletin 2024/15 (21) Application number: 22736093.0 (22) Date of filing: 02.06.2022

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2866; C07K 2317/34; C07K 2317/732; C07K 2317/41; C07K 2317/73; C07K 2317/92; C07K 2317/569; C07K 16/2818; C07K 16/28; A61K 2039/507 (86) International application number: PCT/US2022/032011 (87) International publication number: WO 2022/256563 (08.12.2022 Gazette 2022/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.06.2021 US 202163197271 P 24.08.2021 US 202163236551 P (71) Applicants: Amgen Inc. Thousand Oaks, California 91320 (US) Amgen Research (Munich) GmbH 81477 München (DE)

(72) Inventors: PIERCE, Nathan William Thousand Oaks, California 91320-1799 (US) KIELCZEWSKA, Agnieszka Thousand Oaks, California 91320-1799 (US) CHEN, Wentao Thousand Oaks, California 91320-1799 (US) NOLAN-STEVAUX, Olivier Thousand Oaks, California 91320-1799 (US) BATES, Darren L. Thousand Oaks, California 91320-1799 (US) WINKEL, Lisa 81477 Munich (DE) DAHLHOFF, Christoph 81477 Munich (DE) RAUM, Tobias 81477 Munich (DE) BLUEMEL, Claudia 81477 Munich (DE) HONER, Jonas Karl-Josef 81477 Munich (DE) (74) Representative: Lau, Sarah Jane et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)