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EP 4 348 260 A2

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(88) Date of publication A3: 05.01.2023 (43) Date of publication: 10.04.2024 Bulletin 2024/15 (21) Application number: 22733495.0 (22) Date of filing: 03.06.2022

(51) International Patent Classification (IPC):  G01N 33/574(2006.01) A61K 39/395(2006.01) A61P 35/00(2006.01) A61K 39/39(2006.01) G01N 33/569(2006.01) C07K 16/22(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/22; A61K 2039/505; A61K 2039/545; A61P 35/00 (86) International application number: PCT/US2022/032278 (87) International publication number: WO 2022/256723 (08.12.2022 Gazette 2022/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.06.2021 US 202163202260 P 14.07.2021 US 202163221588 P 14.07.2021 US 202163221843 P 18.10.2021 US 202163256927 P 10.01.2022 US 202263298128 P 25.01.2022 US 202263302999 P 24.02.2022 US 202263313355 P 24.02.2022 US 202263313386 P 25.03.2022 WO PCT/US2022/022063 (71) Applicant: Scholar Rock, Inc. Cambridge, MA 02142 (US)

(72) Inventors: GAN, Lu Cambridge, Massachusetts 02142 (US) SCHURPF, Thomas Cambridge, Massachusetts 02142 (US) CORICOR, George Cambridge, Massachusetts 02142 (US) JACKSON, Justin Cambridge, Massachusetts 02142 (US) LEE-HOEFLICH, Si Tuen Cambridge, Massachusetts 02142 (US) BRUECKNER, Christopher Cambridge, Massachusetts 02142 (US) MARTIN, Constance Cambridge, Massachusetts 02142 (US) FAUCETTE, Ryan Cambridge, Massachusetts 02142 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)