(19)

(11)

EP 4 351 587 A1

(12)

(43) Date of publication: 17.04.2024 Bulletin 2024/16 (21) Application number: 22735029.5 (22) Date of filing: 07.06.2022

(51) International Patent Classification (IPC):  A61K 31/57(2006.01) A61K 31/661(2006.01) A61P 1/00(2006.01) A61P 29/00(2006.01) A61P 35/00(2006.01) A61P 43/00(2006.01) A61K 31/575(2006.01) A61K 31/704(2006.01) A61P 19/02(2006.01) A61P 31/10(2006.01) A61P 37/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/57; A61K 31/575; A61K 31/704; A61K 31/661; A61P 31/10; A61P 35/00; A61P 29/00; A61P 37/00; A61P 19/02; A61P 1/00; A61P 43/00 (86) International application number: PCT/IB2022/055271 (87) International publication number: WO 2022/259129 (15.12.2022 Gazette 2022/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.06.2021 IT 202100014747 (71) Applicant: Consiglio Nazionale Delle Ricerche 00185 Roma (IT)	(72) Inventors: MANZO, Emiliano 80126 Napoli (IT) FONTANA, Angelo 83100 Avellino (IT) GALLO, Carmela 80078 Pozzuoli (IT) (74) Representative: Valenza, Silvia et al Notarbartolo & Gervasi S.p.A. Viale Achille Papa, 30 20149 Milano 20149 Milano (IT)