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EP 4 352 211 A1

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(43) Date of publication: 17.04.2024 Bulletin 2024/16 (21) Application number: 22810794.2 (22) Date of filing: 26.05.2022

(51) International Patent Classification (IPC):  C12N 9/04(2006.01) A61B 5/1486(2006.01) C12Q 1/00(2006.01) C07K 14/80(2006.01) C12N 15/62(2006.01) G01N 27/327(2006.01) (52) Cooperative Patent Classification (CPC): Y02E 60/50; A61B 5/1486; C07K 14/80; C12N 15/62; C12N 9/0006; C12Y 101/05; C12Y 101/9901; C12Q 1/006 (86) International application number: PCT/IL2022/050559 (87) International publication number: WO 2022/249186 (01.12.2022 Gazette 2022/48)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.05.2021 US 202117332718 (71) Applicant: B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University 8410501 Beer Sheva (IL)	(72) Inventors: ALFONTA, Lital 8496500 Omer (IL) ZARIVACH, Raz 8486621 Beer Sheva (IL) GRUSHKA, Jennifer 6228312 Tel Aviv (IL) ALGOV, Itay 6092000 Kadima (IL) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)