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EP 4 352 501 A1

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(43) Date of publication: 17.04.2024 Bulletin 2024/16 (21) Application number: 22820826.0 (22) Date of filing: 06.06.2022

(51) International Patent Classification (IPC):  G01N 33/00(2006.01) G01N 33/53(2006.01) G01N 33/50(2006.01) C07K 16/00(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/6896; G01N 2800/2828 (86) International application number: PCT/US2022/032299 (87) International publication number: WO 2022/260977 (15.12.2022 Gazette 2022/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.06.2021 US 202163197822 P (71) Applicants: Regents of the University of Minnesota Minneapolis, Minnesota 55455-2020 (US) Creighton University Omaha, Nebraska 68178 (US)

(72) Inventors: LARSEN, Peter Anthony Minneapolis, Minnesota 55455 (US) WOLF, Tiffany M. Minneapolis, Minnesota 55455 (US) SCHWABENLANDER, Marc D. Minneapolis, Minnesota 55455 (US) BARTZ, Jason C. Omaha, Nebraska 68178 (US) YUAN, Qi Omaha, Nebraska 68178 (US) (74) Representative: Fish & Richardson P.C.  Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München 80807 München (DE)