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(11)

EP 4 358 999 A1

(12)

(43) Date of publication: 01.05.2024 Bulletin 2024/18 (21) Application number: 22737464.2 (22) Date of filing: 23.06.2022

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) A61K 39/285(2006.01) C12N 15/00(2006.01) A61K 39/215(2006.01) C07K 14/005(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/12; A61K 39/215; A61K 39/285; C07K 14/005; C12N 2710/20022; C12N 2710/20034; C12N 2710/24143; A61P 31/14 (86) International application number: PCT/EP2022/067271 (87) International publication number: WO 2022/269003 (29.12.2022 Gazette 2022/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.06.2021 EP 21382557 31.12.2021 EP 21383245 (71) Applicant: Consejo Superior De Investigaciones Científicas 28006 Madrid (ES)	(72) Inventors: GARCÍA ARRIAZA, Juan Francisco 28006 Madrid (ES) ESTEBAN RODRÍGUEZ, Mariano 28006 Madrid (ES) PÉREZ RAMÍREZ, Patricia 28006 Madrid (ES) LÁZARO FRÍAS, Adrian 28006 Madrid (ES) (74) Representative: Hoffmann Eitle  Hoffmann Eitle S.L.U. Paseo de la Castellana 140, 3a planta Edificio LIMA 28046 Madrid 28046 Madrid (ES)