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EP 4 359 006 A1

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(43) Date of publication: 01.05.2024 Bulletin 2024/18 (21) Application number: 22744043.5 (22) Date of filing: 22.06.2022

(51) International Patent Classification (IPC):  A61K 47/64(2017.01) C12N 15/113(2010.01) C07K 7/64(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/6455; C07K 7/64; C12N 15/113; C12N 2310/11; C12N 2310/3233; C12N 2310/3513; A61P 21/00; C07K 19/00; A01K 2227/105; A01K 2217/072; A01K 2267/0306; A61K 38/00; A61K 31/712; A61P 25/00   C-Sets: A61K 31/712, A61K 2300/00; (86) International application number: PCT/US2022/034517 (87) International publication number: WO 2022/271818 (29.12.2022 Gazette 2022/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.06.2021 US 202163213900 P 01.09.2021 US 202163239671 P 01.09.2021 US 202163239847 P 17.12.2021 US 202163290892 P 17.12.2021 US 202163290960 P 11.01.2022 US 202263298565 P 31.01.2022 US 202263305071 P 25.02.2022 US 202263268577 P 26.02.2022 US 202263314369 P 04.03.2022 US 202263316634 P 08.03.2022 US 202263317856 P 31.03.2022 US 202263326201 P 31.03.2022 US 202263362295 P 04.04.2022 US 202263327179 P 06.05.2022 US 202263339250 P (71) Applicant: Entrada Therapeutics, Inc. Boston, MA 02210 (US)

(72) Inventors: SHEN, Xiulong Boston MA 02210 (US) QIAN, Ziqing Boston MA 02210 (US) DOUGHERTY, Patrick Boston MA 02210 (US) KHEIRABADI, Mahboubeh Boston MA 02210 (US) LI, Xiang Boston MA 02210 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)