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EP 4 363 564 A1

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(43) Date of publication: 08.05.2024 Bulletin 2024/19 (21) Application number: 21948680.0 (22) Date of filing: 29.06.2021

(51) International Patent Classification (IPC):  C12N 9/12(2006.01) C12Q 1/6869(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6869; C12N 9/1252; C12Y 207/07007; C12N 15/52; C12Q 1/6844   C-Sets: C12Q 1/6869, C12Q 2521/101, C12Q 2525/186, C12Q 2537/155; C12Q 1/6844, C12Q 2521/101, C12Q 2525/186, C12Q 2535/122, C12Q 2537/155; C12Q 1/6844, C12Q 2521/101, C12Q 2525/186; (86) International application number: PCT/US2021/070785 (87) International publication number: WO 2023/277953 (05.01.2023 Gazette 2023/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: Agilent Technologies, Inc. Santa Clara, CA 95051-7201 (US)

(72) Inventors: CAYOUETTE, Michelle Santa Clara, California 95051-7201 (US) FOX, Jeffrey Santa Clara, California 95051-7201 (US) HANSEN, Connie Santa Clara, California 95051-7201 (US) HOGREFE, Holly Santa Clara, California 95051-7201 (US) WU, Weidong Santa Clara, California 95051-7201 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)