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EP 4 366 767 A2

(12)

(88) Date of publication A3: 05.10.2023 (43) Date of publication: 15.05.2024 Bulletin 2024/20 (21) Application number: 22838408.7 (22) Date of filing: 07.07.2022

(51) International Patent Classification (IPC):  A61K 39/215(2006.01) C07H 21/02(2006.01) (52) Cooperative Patent Classification (CPC): C07K 2319/35; C12P 21/02; C12Q 1/6897; C12N 2770/20022; C12N 2830/15; C12N 2740/16043; C07K 14/005; C12N 15/86; C12N 2770/20034; A61K 39/12; A61K 2039/53; C07K 2317/14; C07K 16/1003 (86) International application number: PCT/US2022/036367 (87) International publication number: WO 2023/283342 (12.01.2023 Gazette 2023/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.07.2021 US 202163219587 P 08.07.2021 US 202163219596 P 08.07.2021 US 202163219599 P 19.04.2022 US 202263332378 P (71) Applicant: Temple University - Of The Commonwealth System of Higher Education Philadelphia, PA 19122 (US)

(72) Inventor: HU, Wenhui Cherry Hill, New Jersey 08003 (US) (74) Representative: Leonard, Thomas Charles et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)