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EP 4 367 140 A1

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(43) Date of publication: 15.05.2024 Bulletin 2024/20 (21) Application number: 22837100.1 (22) Date of filing: 06.07.2022

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 15/13(2006.01) A61K 39/00(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 39/39; C07K 16/2878; C07K 16/2818; C07K 2317/74; C07K 2317/75; C07K 2317/76; C07K 2317/90; C07K 2317/92; C07K 2317/24; C07K 2317/33; C07K 2317/34; C07K 2317/732; A61K 2039/507; A61K 2039/505 (86) International application number: PCT/IB2022/000409 (87) International publication number: WO 2023/281313 (12.01.2023 Gazette 2023/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.07.2021 US 202163219175 P (71) Applicant: Hifibio (HK) Limited Central (CN)

(72) Inventors: BELTRAMINELLI, Nicola Arturo, Aldo Cambridge, MA 02139 (US) WATKINS, Jennifer Cambridge, MA 02139 (US) ADRIAN, Francisco Cambridge, MA 02139 (US) ZHANG, Qian Cambridge, MA 02139 (US) RAUE, Andreas Cambridge, MA 02139 (US) MARY, Pascaline Cambridge, MA 02139 (US) SCHWEIZER, Liang Cambridge, MA 02139 (US) WEI, Shuo Cambridge, MA 02139 (US) DELINCE, Matthieu Cambridge, MA 02139 (US) (74) Representative: CH Kilger Anwaltspartnerschaft mbB  Fasanenstraße 29 10719 Berlin 10719 Berlin (DE)