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EP 4 367 252 A2

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(88) Date of publication A3: 16.02.2023 (43) Date of publication: 15.05.2024 Bulletin 2024/20 (21) Application number: 22838112.5 (22) Date of filing: 04.07.2022

(51) International Patent Classification (IPC):  C12N 15/86(2006.01) A61K 35/76(2015.01) A61K 9/19(2006.01) A61K 47/26(2006.01) A61K 47/40(2006.01) C12N 7/00(2006.01) A61K 9/08(2006.01) A61K 47/18(2017.01) A61K 47/34(2017.01) A61K 47/02(2006.01) (52) Cooperative Patent Classification (CPC): Y02A 50/30; A61K 9/08; A61K 9/19; A61K 35/76; A61K 47/40; C12N 15/86; C12N 2750/14143; C12N 2750/14151 (86) International application number: PCT/RU2022/050212 (87) International publication number: WO 2023/282796 (12.01.2023 Gazette 2023/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.07.2021 RU 2021120143 (71) Applicant: Joint Stock Company "Biocad" 198515, Saint Petersburg (RU)

(72) Inventors: FEDORENKO, Lina Igorevna Bronnitsy, 140171 (RU) LOMKOVA, Ekaterina Aleksandrovna Saint Petersburg, 196066 (RU) IAKOVLEV, Aleksandr Olegovich Moscow, 109651 (RU) SOZONOVA, Aleksandra Aleksandrovna Saint Petersburg, 198205 (RU) DVORIANKINA, Marina Konstantinovna Odintsovsky District, 143080 (RU) MOROZOV, Dmitry Valentinovich Saint Petersburg, 190000 (RU) (74) Representative: Held, Stephan  Meissner Bolte Patentanwälte Rechtsanwälte Partnerschaft mbB Widenmayerstraße 47 80538 München 80538 München (DE)