(19)

(11)

EP 4 377 292 A1

(12)

(43) Date of publication: 05.06.2024 Bulletin 2024/23 (21) Application number: 22848817.7 (22) Date of filing: 20.07.2022

(51) International Patent Classification (IPC):  C07C 211/46(2006.01) C07K 16/32(2006.01) A61P 35/00(2006.01) C07C 69/00(2006.01) C07K 16/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/32; A61P 35/00; C07K 2317/24; C07D 491/22 (86) International application number: PCT/IL2022/050782 (87) International publication number: WO 2023/007481 (02.02.2023 Gazette 2023/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.07.2021 IL 28520821 (71) Applicants: Ramot at Tel-Aviv University Ltd. 6130201 Tel-Aviv (IL) Merck Patent GmbH 64293 Darmstadt (DE)	(72) Inventors: SHABAT, Doron 6139201 Tel Aviv (IL) SATCHI-FAINARO, Ronit 6139201 Tel Aviv (IL) SWEENEY-LASCH, Stanley 64283 Darmstadt (DE) DEUTSCH, Carl 64646 Heppenheim (DE) BERGER, Nir 4636427 Herzliya (IL) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstrasse 3 81675 München 81675 München (DE)