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EP 4 381 064 A1

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(43) Date of publication: 12.06.2024 Bulletin 2024/24 (21) Application number: 22761488.0 (22) Date of filing: 03.08.2022

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) C12N 5/0789(2010.01) C12N 15/113(2010.01) C12N 15/90(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2310/20; C12N 15/113; C12N 15/11; C12N 2320/11; C12N 2750/14143; C12N 15/907; C12N 2501/125; C12N 2501/2303; C12N 2501/2306; C12N 2501/145; C12N 2501/26; C12N 2501/22; C12N 2510/00; C12N 5/0647; A61K 48/005 (86) International application number: PCT/EP2022/071868 (87) International publication number: WO 2023/012237 (09.02.2023 Gazette 2023/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.08.2021 EP 21189707 (71) Applicant: Eberhard Karls Universität Tübingen, Medizinische Fakultät 72074 Tübingen (DE)	(72) Inventors: SKOKOWA, Julia 72127 Kusterdingen (DE) RITTER, Malte 72072 Tuebingen (DE) NASRI, Masoud 72074 Tuebingen (DE) (74) Representative: Witte, Weller & Partner Patentanwälte mbB  Postfach 10 54 62 70047 Stuttgart 70047 Stuttgart (DE)