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EP 4 384 152 A1

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(43) Date of publication: 19.06.2024 Bulletin 2024/25 (21) Application number: 22856484.5 (22) Date of filing: 09.08.2022

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) A61P 35/00(2006.01) A61K 31/136(2006.01) A61K 31/473(2006.01) A61K 39/395(2006.01) C07K 16/28(2006.01) A61K 31/337(2006.01) (52) Cooperative Patent Classification (CPC): Y02A 50/30; A61K 31/337; A61P 35/00; C07K 16/2818; A61K 2039/507; C07K 2317/565; C07K 16/2803; C07K 2317/56; A61K 2039/545; A61K 2039/55; A61K 39/39558; A61K 45/06; A61K 31/513; A61K 33/243; A61K 31/7068; A61K 31/555   C-Sets: A61K 31/7068, A61K 2300/00; A61K 31/555, A61K 2300/00; A61K 39/39558, A61K 2300/00; A61K 31/513, A61K 2300/00; A61K 33/243, A61K 2300/00; A61K 31/337, A61K 2300/00; (86) International application number: PCT/US2022/039767 (87) International publication number: WO 2023/018677 (16.02.2023 Gazette 2023/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 10.08.2021 US 202163231525 P 04.04.2022 US 202263327070 P (71) Applicant: Merck Sharp & Dohme LLC Rahway, New Jersey 07065 (US)

(72) Inventors: HEALY, Jane Anne Rahway, New Jersey 07065-0907 (US) SHRAWANKUMAR JHA, Sujata Dallas, Texas 75230 (US) KEENAN, Tanya Boston, Massachusetts 02115-5727 (US) SIEGEL, Abby Rahway, New Jersey 07065-0907 (US) PINHEIRO, Elaine, M. Needham, Massachusetts 02494 (US) SNYDER, Alexandra New York, New York 10028 (US) CAI, Mingmei Boston, Massachusetts 02115-5727 (US) (74) Representative: Merck Sharp & Dohme LLC  120 Moorgate London EC2M 6UR London EC2M 6UR (GB)