(19)

(11)

EP 4 384 278 A1

(12)

(43) Date of publication: 19.06.2024 Bulletin 2024/25 (21) Application number: 22947055.4 (22) Date of filing: 01.11.2022

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07C 211/42(2006.01) A61K 31/122(2006.01) C07C 211/30(2006.01) C07C 50/12(2006.01) (52) Cooperative Patent Classification (CPC): C07C 211/30; C07C 211/42; A61P 35/00; A61K 31/122; C07D 211/00 (86) International application number: PCT/TR2022/051215 (87) International publication number: WO 2024/085824 (25.04.2024 Gazette 2024/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 19.10.2022 TR 202215931 (71) Applicants: Istinye Üniversitesi 34010 Zeytinburnu Istanbul (TR) Istanbul Üniversitesi - Cerrahpasa Rektörlügü 34320 Avcilar/Istanbul (TR)

(72) Inventors: GÖKMEN, Zeliha 34320 Avcilar/Istanbul (TR) ULUKAYA, Engin Zeytinburnu/Istanbul (TR) AKAR, Remzi Okan Zeytinburnu/Istanbul (TR) (74) Representative: Yalçiner Patent and Consulting Ltd.  Tunus Caddesi 85/3-4 Kavaklidere 06680 Ankara 06680 Ankara (TR)