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(11)

EP 4 384 819 A1

(12)

(43) Date of publication: 19.06.2024 Bulletin 2024/25 (21) Application number: 22758077.6 (22) Date of filing: 31.07.2022

(51) International Patent Classification (IPC):  G01N 30/00(2006.01) G01N 33/574(2006.01) G01N 33/50(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/57492; G01N 33/5005 (86) International application number: PCT/US2022/038984 (87) International publication number: WO 2023/018567 (16.02.2023 Gazette 2023/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.08.2021 US 202163230779 P (71) Applicant: University of Rochester Rochester, NY 14642 (US)	(72) Inventors: MCGRATH, James, Lionel Fairport, NY 14450 (US) FLAX, Jonathan, David Rochester, NY 14620 (US) LUCAS, Kilean, Scott Billerica, MA 01821 (US) WALKER, Samuel, Norman Rochester, NY 14607 (US) (74) Representative: Michalski Hüttermann & Partner Patentanwälte mbB  Kaistraße 16A 40221 Düsseldorf 40221 Düsseldorf (DE)