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EP 4 387 992 A1

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(43) Date of publication: 26.06.2024 Bulletin 2024/26 (21) Application number: 22777504.6 (22) Date of filing: 19.08.2022

(51) International Patent Classification (IPC):  C07K 14/725(2006.01) A61K 48/00(2006.01) C12N 5/0783(2010.01) C12N 15/90(2006.01) A61K 35/17(2015.01) A61P 35/00(2006.01) C12N 9/22(2006.01) (52) Cooperative Patent Classification (CPC): A61K 48/005; A61P 35/00; C07K 14/7051; C12N 5/0636; C12N 9/22; C12N 2510/00; C12N 15/1138; C12N 2310/20; A61K 2239/47; A61K 39/464471; A61K 2239/31; A61K 2239/38; A61K 39/4631; A61K 39/4611 (86) International application number: PCT/US2022/075193 (87) International publication number: WO 2023/023635 (23.02.2023 Gazette 2023/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 20.08.2021 US 202117407606 (71) Applicant: Wisconsin Alumni Research Foundation Madison, WI 53726 (US)

(72) Inventors: SAHA, Krishanu Middleton, Wisconsin 53562 (US) CAPITINI, Christian Matthew Madison, Wisconsin 53711 (US) MUELLER, Katherine Paige Madison, Wisconsin 53705 (US) PISCOPO, Nicole Jenine Madison, Wisconsin 53703 (US) DAS, Amritava Madison, Wisconsin 53705 (US) FORSBERG, Matthew Hull Madison, Wisconsin 53705 (US) SARASPE, Louise Armie Madison, Wisconsin 53703 (US) (74) Representative: Dehns  St. Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)