(19)

(11)

EP 4 388 012 A1

(12)

(43) Date of publication: 26.06.2024 Bulletin 2024/26 (21) Application number: 22859437.0 (22) Date of filing: 19.08.2022

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) G01N 33/569(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2833; C07K 2317/52; C07K 2317/73; C07K 2317/565; C07K 2317/33; C07K 2317/34; C07K 2317/622; C07K 2317/92; C07K 2317/24 (86) International application number: PCT/US2022/075241 (87) International publication number: WO 2023/023663 (23.02.2023 Gazette 2023/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 20.08.2021 US 202163235535 P 15.09.2021 WO PCT/US2021/050537 (71) Applicants: Duke University Durham, NC 27705 (US) The Chancellor, Masters and Scholars of The University of Oxford Oxford, Oxfordshire OX1 2JD (GB) Li, Dapeng Durham, NC 27705 (US) McMichael, Andrew, James Oxford OX1 2JD (GB) Brackenridge, Simon Oxford OX1 2JD (GB) Gillespie, Geraldine Oxford OX1 2JD (GB) Azoitei, Mihai Durham, NC 27705 (US) Walters, Lucy, C. Oxford OX1 2JD (GB) Saunders, Kevin, O. Durham, NC 27705 (US) Haynes, Barton, F. Durtham, NC 27705 (US)

(72) Inventors: LI, Dapeng Durham, NC 27705 (US) MCMICHAEL, Andrew, James Oxford OX1 2JD (GB) BRACKENRIDGE, Simon Oxfrod OX1 2JD (GB) GILLESPIE, Geraldine Oxford OX1 2JD (GB) AZOITEI, Mihai Durham, NC 27705 (US) WALTERS, Lucy, C. Oxford OX1 2JD (GB) SAUNDERS, Kevin, O. Durham, NC 27705 (US) HAYNES, Barton, F. Durtham, NC 27705 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)