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EP 4 392 052 A1

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(43) Date of publication: 03.07.2024 Bulletin 2024/27 (21) Application number: 22862231.2 (22) Date of filing: 23.08.2022

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) A61P 11/00(2006.01) C07K 4/00(2006.01) C07K 14/00(2006.01) A61K 9/00(2006.01) C07K 7/06(2006.01) C07K 7/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 11/00; A61K 38/00; C07K 14/785 (86) International application number: PCT/US2022/075356 (87) International publication number: WO 2023/028491 (02.03.2023 Gazette 2023/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 23.08.2021 US 202117409642 (71) Applicants: Arizona Board of Regents on behalf of The University of Arizona Tucson, AZ 85713 (US) Raesedo, LLC Tucson, AZ 85704 (US)

(72) Inventors: LEDFORD, Julie Tucson, AZ 85724 (US) KRAFT, Monica New York, NY 10029 (US) VAGNER, Josef Tucson, AZ 85721 (US) (74) Representative: Jilderda, Anne Ayolt  LIOC Patents & Trademarks Zwaanstraat 31 L 5651 CA Eindhoven 5651 CA Eindhoven (NL)