(19)

(11)

EP 4 392 069 A2

(12)

(88) Date of publication A3: 08.06.2023 (43) Date of publication: 03.07.2024 Bulletin 2024/27 (21) Application number: 22879031.7 (22) Date of filing: 07.10.2022

(51) International Patent Classification (IPC):  A61K 47/12(2006.01) A61K 31/4375(2006.01) A61K 8/37(2006.01) A61P 19/02(2006.01) A61K 47/24(2006.01) A61K 8/14(2006.01) A61K 8/92(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/4375; A61P 19/02; A61K 9/1272; A61K 9/0014 (86) International application number: PCT/SG2022/050720 (87) International publication number: WO 2023/059270 (13.04.2023 Gazette 2023/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: KH MA MD TN (30) Priority: 08.10.2021 SG 10202111225V (71) Applicant: National University of Singapore Singapore 119077 (SG)	(72) Inventors: LEE, Choon Keong Singapore 119077 (SG) PASTORIN, Giorgia Singapore 119077 (SG) GOH, Wei Jiang Singapore 119077 (SG) TOH, Wei Seong Singapore 119077 (SG) ZHANG, Shipin Singapore 119077 (SG) (74) Representative: Fuchs Patentanwälte Partnerschaft mbB  Tower 185 Friedrich-Ebert-Anlage 35-37 60327 Frankfurt am Main 60327 Frankfurt am Main (DE)