(19)

(11)

EP 4 392 409 A1

(12)

(43) Date of publication: 03.07.2024 Bulletin 2024/27 (21) Application number: 22765696.4 (22) Date of filing: 19.08.2022

(51) International Patent Classification (IPC):  C07D 241/26(2006.01) A61K 31/498(2006.01) A61K 31/4965(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 241/26 (86) International application number: PCT/US2022/040953 (87) International publication number: WO 2023/027966 (02.03.2023 Gazette 2023/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.08.2021 US 202163236659 P 30.12.2021 US 202163295494 P 04.03.2022 US 202263316939 P 17.05.2022 US 202263364860 P (71) Applicant: Biomea Fusion, Inc. Redwood City, CA 94063 (US)

(72) Inventors: BUTLER, Thomas Redwood City, California 94063 (US) PALMER, James T. Redwood City, California 94063 (AU) SPERANDIO, David Redwood City, California 94063 (US) WANG, Xiaodong Redwood City, California 94063 (US) LIN, Nan-Horng Redwood City, California 94063 (US) KIRSCHBERG, Thorsten A. Redwood City, California 94063 (US) UNGASHE, Solomon B. Redwood City, California 94063 (US) SQUIRES, Neil Howard Redwood City, California 94063 (US) UPASANI, Ravindra Redwood City, California 94063 (US) SU, Yongli Redwood City, California 94063 (US) PHAN, Thu Redwood City, California 94063 (US) ADAM, Amna Trinity-Turjuman Redwood City, California 94063 (US) (74) Representative: Petty, Catrin Helen et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)