(19)
(11) EP 4 392 557 A1

(12)

(43) Date of publication:
03.07.2024 Bulletin 2024/27

(21) Application number: 22768417.2

(22) Date of filing: 23.08.2022
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/113; C12N 2310/20
(86) International application number:
PCT/EP2022/073414
(87) International publication number:
WO 2023/025767 (02.03.2023 Gazette 2023/09)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 23.08.2021 EP 21192657

(71) Applicant: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
13125 Berlin (DE)

(72) Inventors:
  • RAJEWSKY, Peter Klaus Georg
    10707 Berlin (DE)
  • CHU, Van Trung
    10178 Berlin (DE)
  • TRAN, Ngoc Tung
    13435 Berlin (DE)
  • LI, Xun
    13409 Berlin (DE)
  • KÜHN, Ralf
    13187 Berlin (DE)

(74) Representative: Hertin und Partner Rechts- und Patentanwälte PartG mbB 
Kurfürstendamm 54/55
10707 Berlin
10707 Berlin (DE)

   


(54) METHOD FOR CAS9 NICKASE-MEDIATED GENE EDITING