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EP 4 396 844 A1

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(43) Date of publication: 10.07.2024 Bulletin 2024/28 (21) Application number: 22773566.9 (22) Date of filing: 31.08.2022

(51) International Patent Classification (IPC):  G16H 50/70(2018.01) G16H 20/10(2018.01) (52) Cooperative Patent Classification (CPC): G16H 10/60; G16H 20/10; G16H 50/70 (86) International application number: PCT/US2022/042262 (87) International publication number: WO 2023/034453 (09.03.2023 Gazette 2023/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 31.08.2021 US 202163238851 P 30.09.2021 US 202163250912 P 03.06.2022 WO PCT/US2022/032250 29.07.2022 WO PCT/US2022/038941 (71) Applicant: Guardant Health, Inc. Palo Alto, CA 94304 (US)

(72) Inventors: KUMAR, Naveen Palo Alto, California 94304 (US) ZHANG, Jingwen Palo Alto, California 94304 (US) SUBRAMANIAN, Nisha Palo Alto, California 94304 (US) NAYAK, Gautam Palo Alto, California 94304 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)