(19)
(11) EP 4 397 755 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
01.01.2025 Bulletin 2025/01

(43) Date of publication A2:
10.07.2024 Bulletin 2024/28

(21) Application number: 24153256.3

(22) Date of filing: 14.12.2012
(51) International Patent Classification (IPC): 
A61K 38/16(2006.01)
A61K 8/65(2006.01)
A61K 38/18(2006.01)
A61K 38/27(2006.01)
A61K 38/30(2006.01)
A61P 5/18(2006.01)
A61P 17/00(2006.01)
A61P 19/00(2006.01)
A61P 19/04(2006.01)
C12N 9/52(2006.01)
 A61K 8/49(2006.01)
A61K 38/17(2006.01)
A61K 38/19(2006.01)
A61K 38/29(2006.01)
A61K 47/64(2017.01)
A61P 5/20(2006.01)
A61P 17/14(2006.01)
A61P 19/10(2006.01)
A61Q 7/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 38/29; A61K 8/4913; A61K 8/65; A61Q 7/00; A61K 47/64; A61K 38/179; A61K 38/18; A61K 38/1825; A61K 38/1841; A61K 38/1858; A61K 38/1866; A61K 38/193; A61K 38/30; A61K 38/00; A61K 38/1808; A61K 38/1875; A61K 38/27; C12N 9/52; C12Y 304/24003; A61P 17/00; A61P 17/14; A61P 19/00; A61P 19/04; A61P 19/10; A61P 5/18; A61P 5/20; Y02A 50/30
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 14.12.2011 US 201161570620 P
09.02.2012 US 201261596869 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
20184066.7 / 3808365
18173596.0 / 3391899
12857691.5 / 2790717

(71) Applicants:
  • The Board of Trustees of the University of Arkansas
    Little Rock, AR 72207 (US)
  • The Kitasato Institute
    Tokyo 108-8641 (JP)
  • Montefiore Medical Center
    Bronx, NY 10467 (US)
  • National University Corporation Kagawa University
    Takamatsu-shi, Kagawa 760-8521 (JP)

(72) Inventors:
  • SAKON, Joshua
    Fayetteville AR, 72701 (US)
  • PHILOMINATHAN SAGAYA, Theresa, Leena
    Cheshire CT, 06410 (US)
  • KATIKANENI, Ranjitha
    New York, 10471-1700 (US)
  • MATSUSHITA, Osama
    Okayama, 700-8558 (JP)
  • PONNAPAKKAM, Tulasi
    NEW YORK, 10471-1700 (US)
  • KOIDE, Takaki
    TOKYO, 169-8555 (JP)
  • GENSURE, Robert, C.
    NEW YORK, 10467 (US)
  • NISHI, Nozomu
    KAGAWA, 760-8521 (JP)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN


(57) Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.





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