(19)

(11)

EP 4 398 922 A1

(12)

(43) Date of publication: 17.07.2024 Bulletin 2024/29 (21) Application number: 22868082.3 (22) Date of filing: 08.09.2022

(51) International Patent Classification (IPC):  A61K 36/19(2006.01) A61K 36/31(2006.01) A61K 36/88(2006.01) A61K 45/06(2006.01) A61K 36/9068(2006.01) A61K 36/42(2006.01) A61K 36/185(2006.01) A61P 1/16(2006.01) (52) Cooperative Patent Classification (CPC): A61K 36/42; A61K 36/31; A61K 36/9068; A61K 45/06; A61P 1/16; A61K 36/19; A61K 36/8965; A61K 36/47   C-Sets: A61K 36/42, A61K 2300/00; A61K 36/47, A61K 2300/00; A61K 36/8965, A61K 2300/00; A61K 36/19, A61K 2300/00; A61K 36/9068, A61K 2300/00; A61K 36/31, A61K 2300/00; (86) International application number: PCT/US2022/042960 (87) International publication number: WO 2023/039105 (16.03.2023 Gazette 2023/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.09.2021 US 202117469566 (71) Applicant: Karallief, Inc. Boston, MA 02116 (US)	(72) Inventor: RAJENDRAN, Krishna Cambridge, Massachusetts 02138 (US) (74) Representative: Finnegan Europe LLP  1 London Bridge London SE1 9BG London SE1 9BG (GB)