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EP 4 399 303 A1

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(43) Date of publication: 17.07.2024 Bulletin 2024/29 (21) Application number: 22800032.9 (22) Date of filing: 08.09.2022

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) C12N 15/86(2006.01) C12N 15/11(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/111; C12N 15/113; C12N 2310/20; C12N 15/86; C12N 2330/51; C12N 2760/20143; C12N 2760/20151; C12N 2760/20152 (86) International application number: PCT/US2022/076106 (87) International publication number: WO 2023/039468 (16.03.2023 Gazette 2023/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.09.2021 US 202163241964 P (71) Applicants: Beam Therapeutics, Inc. Cambridge, MA 02139 (US) Ran, Fei Cambridge, Massachusetts 02139 (US) Lin, ChieYu Cambridge, Massachusetts 02139 (US)

(72) Inventors: RAN, Fei Cambridge, Massachusetts 02139 (US) LIN, ChieYu Cambridge, Massachusetts 02139 (US) (74) Representative: De Clercq & Partners  Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem 9830 Sint-Martens-Latem (BE)